Longevity, biohacking and skin regeneration

NAD+: the hype, the science, and what it means for your skin

NAD+ (nicotinamide adenine dinucleotide) is an essential cellular coenzyme involved in energy metabolism, DNA repair, and cellular renewal. Often referred to as a key molecule of healthy ageing, NAD+ supports the biological processes required for optimal skin function, resilience, and longevity. As NAD+ levels naturally decline with age, skin may experience reduced cellular efficiency, slower regeneration, and visible signs of ageing, including fine lines, dullness, and loss of resilience.

While topical skincare cannot directly replenish cellular NAD+ stores, ingredients that support NAD+-dependent pathways may help promote skin renewal, barrier function, and long-term skin health. Emerging research suggests that supporting NAD+ production may help enhance cellular energy, strengthen barrier integrity, reduce oxidative stress and inflammation, and improve skin resilience, texture, and overall skin longevity.

how does dermalogica support NAD+?

At Dermalogica, our approach to NAD+ is rooted in the science of skin longevity. This growing understanding of NAD+ and its role in cellular health informs the development of Future Code Booster, a formula designed to support the skin’s natural capacity for repair, resilience, and regeneration. By helping to optimise the biological processes associated with healthy skin function, it supports healthier, more resilient skin over time.

Future Code Booster sits within a broader Dermalogica approach to skin longevity, alongside formulas such as Dynamic Skin Sculptor and Multivitamin Power Recovery Cream, which incorporate ingredients and technologies that support repair, resilience, and healthy-looking skin over time.

exosomes: the delivery system for repair

Exosomes are microscopic extracellular vesicles that act as the skin’s natural communication system. Released by cells, they transport signalling molecules that help regulate key biological processes involved in repair, regeneration, and tissue homeostasis.

Their role in cellular communication has made exosomes a significant area of interest in regenerative skin science and skin longevity research. By helping to coordinate the processes that underpin skin resilience and recovery, exosome-inspired technologies are shaping the future of advanced skincare designed to support long-term skin health.

how does dermalogica use exosome technology?

Advances in exosome and extracellular vesicle research within regenerative skin science have informed the formulations of Exo Booster and Phyto Nature E2. Positioned within a skin longevity framework, these formulations help support key mechanisms associated with resilience, recovery, barrier function, and long-term skin health

Dermalogica Exo Booster is formulated for integration across professional medi-aesthetic procedures, including microneedling, where controlled dermal stimulation activates the skin’s innate repair and regenerative pathways. Exo Booster is designed to enhance the efficiency of ingredient interaction with the skin and support visible skin performance. Its formulation approach centres on optimising the skin’s natural biological processes, particularly those involved in cellular signalling, tissue regeneration, and adaptive responses to environmental and age-related stressors.

Taking what we know from the treatment room, and the way exosome-inspired skincare is emerging as a key category in regenerative aesthetics, Phyto Nature E² brings this approach to daily at-home care. Formulated with a Regenerative Exosome Blend featuring turmeric stem cells and Acacia Senegal Extract it supports intercellular signalling and visible skin renewal, helping to improve the appearance of fine lines, texture, radiance, and overall skin vitality over time. This leave-on daily treatment can be incorporated into an existing skincare routine as a standalone regenerative solution or used alongside professional treatments to help maintain results between appointments.

peptides: your precision signals for skin health

Peptides are short-chain amino acids that act as targeted messengers within the skin, helping to support key biological processes linked to visible skin health and resilience. In advanced skincare, peptides are used to help signal the skin to support collagen production, improve the appearance of firmness, and enhance overall texture and tone.

Clinically inspired formulations often incorporate peptides to help address visible signs of aging such as fine lines, loss of elasticity, and uneven skin texture, while also supporting the skin’s natural barrier function. Peptides have become a key trending skincare ingredient due to increasing demand for high-performance, science-led formulas and advancements in peptide technology that enable improved stability, precision, and skin compatibility. When used consistently, peptides help promote smoother, stronger, and more resilient-looking skin, making them a cornerstone of modern anti-aging skincare.

how does dermalogica use peptide techonology?

Dermalogica integrates peptide technology across its professional skincare systems. Peptides help signal key biological pathways involved in collagen synthesis, extracellular matrix support, and tissue repair, all of which are critical to maintaining long-term skin health and function.

This biomimetic approach is most notably featured in the Pro-Collagen Banking Serum, alongside peptide-enhanced treatments across its eye and moisturising ranges. Using advanced delivery systems to improve stability and bioavailability, these formulations are designed to optimise peptide activity within the skin, supporting improved firmness, density, and overall resilience as part of a preventative, performance-led skincare strategy.

growth factors: intelligent design, biologically led

Growth factors are advanced, bioactive signaling proteins that help support the skin’s natural renewal, repair, and collagen production processes. As these essential messengers decline with age, skin can lose density, firmness, and resilience, leading to visible signs of aging such as fine lines and reduced elasticity.

Biomimetic growth factor technology is designed to help support these pathways, helping to improve the appearance of skin density, strengthen the skin barrier, and promote smoother, more youthful-looking skin. Formulated with advanced delivery systems to enhance stability and absorption, this targeted approach helps optimise skin regeneration for healthier, visibly revitalised skin over time.

how does dermalogica use growth factors?

Growth factor technology can be found within the new Smart Eye Density serum. The lightweight eye serum has been specifically formulated to target hollow eyes and the delicate skin around the eyes. Formulated for stability, a growth factor complex delivered via an Oleosomal system visibly plumps the eye area for a redensified appearance.

By harnessing growth factor complex technology, Smart Eye Density has been clinically proven to rebuild under eye density by 129% in 4 weeks, with 97% also confirming their undereyes felt refined, resilient, reinforced, and revitalised after 4 weeks of use.

the science of sensitive skin: building resilient and healthy skin barriers

Skin health is the principle that has shaped every Dermalogica formulation, treatment protocol, and professional education programme for over 40 years. Every product we develop is rooted in evidence-based research, combining science-backed active ingredients with clinical performance to deliver visible results without compromising barrier integrity or overall skin health.

Central to this is a deep, science-led understanding of skin sensitivity. Dermalogica supports you to understand the difference between immunogenic inflammation, driven by allergen and irritant exposure, and neurogenic inflammation, triggered by sensory nerve activation.

Understanding these distinct pathways enables professional skin therapists to move beyond symptom management and address the true causes of reactivity. Our protocols and formulations are built on the foundations of peer-reviewed science, clinical evidence, and the professional expertise to apply it with confidence in every treatment room.

from daily skin health to targeted sensitivity relief

For over 40 years, our approach to skin has been centred on the principle that consistent, barrier-conscious care is the most effective investment in long-term skin health. Our Daily Skin Health franchise, featuring iconic products including Daily Microfoliant, Special Cleansing Gel, and Skin Smoothing Cream, are trusted cornerstones of professional practice, designed to support healthy skin function every day and across all skin types.

For clients with sensitive or sensitised skin requiring targeted support, the Ultracalming franchise has been formulated with sensitive, sensitized, reactive, eczema-prone, and rosacea-prone skin in mind. It is clinically proven to reduce visible signs of redness and irritation while supporting the skin’s natural barrier function. In clinical studies, 84% saw a reduction in redness and 90% said their skin appeared healthier after 30 days of using the Ultracalming stabilizing repair cream.

The newest addition to the franchise, Stabilizing Repair Serum, extends this professional expertise to both face and body. Clinically proven to help provide immediate relief from visible signs of inflammation including itching, stinging and tightness, this lightweight serum also works to fortify the skin’s moisture barrier, helping to prevent future reactivity.

Northern Truffle Extract helps block the TRPV1 receptor pathway responsible for triggering the neurogenic inflammation cycle, while a biometric complex with skin-replenishing lipids, phytosterols, and ceramide-like compounds deeply nourishes and helps seal in moisture. Encapsulated Calcium is crucial for replenishing the skin, and Resurrection Plant hydrates, replenishes, and restores skin’s resilience.

the role of oxygen in skin health and why levels decline with with age

Oxygen is a crucial compound for our survival, but it also plays an important role in our skin health. Skin cells are aerobic so they require oxygen to carry out key functions including energy production and cell turnover. As we age, the body naturally redirects oxygen toward vital organs, reducing availability at the skin’s surface.

Combined with the effects of environmental aggressors such as pollution and UV exposure, this oxygen-deprivation can leave skin cells functioning below their optimal level therefore contributing visibly to fine lines, reduced firmness, uneven tone, and a dull-looking complexion over time.

how dermalogica uses oxygen in professional skincare

While skin ageing is a multifactorial process, Dermalogica formulates the Phyto Nature Oxygen Cream with several ingredients that help to combat the effects of external factors that deplete oxygen levels at the skin’s surface. The formula supports clients on their skin health journey and is clinically studies showed skin to look visibly firmer and more lifted after 1 week of use.

Formulated with ligustrum lucidum seed extract, glycogen, and nasturtium flower, phyto nature oxygen cream helps optimise oxygen absorption at the skin’s surface, supporting energy production and cell turnover over time. Astragalus, electric daisy flower, and luffa root help support skin resilience, firmness, and the appearance of texture. Meanwhile, antioxidant-rich camellia oil helps soothe skin and maintain the skin barrier, contributing to overall skin health.