clinical trials & proven results
clinical results: the science behind dermalogica
We continuously invest in independent clinical studies to ensure our products achieve demonstrable, measurable results for skin health.
science-backed skin health
understanding clinically proven results
At Dermalogica, we invest in independent clinical studies that demonstrate the effectiveness of our formulas. Results are measured objectively, often through imaging techniques or instrumental skin analysis.
Our clinical studies meet the following standards: a minimum of 30 participants, formulations applied under dermatological supervision in realistic conditions, and all results measured objectively with imaging techniques and instrumental skin analysis.
science backed skin health
the importance of clinical evidence
Clinical trials ensure integrity, honesty and efficacy. They allow us to prove, with scientific data, that our products achieve visible results for different skin types and conditions. Using clinical data gives our treatments enhanced authority and legitimacy, and increases confidence with education-led consultations in retail.
At Dermalogica, we use three methods of clinical design to gather our results. Objective in-vivo assessments and subjective assessments help us understand the consumer experience and visible differences that can be made to overall skin health and appearance. Meanwhile, the in-vitro testing demonstrates the impact at a cellular level, allowing us to confidently and credibly highlight the differences to skin health.
three methods of clinical design used by Dermalogica
objective in-vivo
helps us understand the consumer experience through standardised and measurable data.
subjective in-vivo
focuses on understanding the consumer experience, the results they may feel and how their skin health may visibly change.
objective in-vitro
measures the impact at a cellular level, allowing us to confidently and credibly highlight the differences to skin health.
the dermalogica laboratory
Our in-house laboratory, led by Dr Bob in California, develops every formulation at Dermalogica. Dr Bob and his team analyse the latest active ingredients, develop innovative textures and thoroughly test all formulas from initial concept to finished product.
Having access to our own research facilities and patented ingredient technology uniquely positions us to deliver on our promise of scientifically sound, professional and sustainable products.
the dermalogica laboratory
meet Dr Bob
Dr Bob is one of the leading experts in skin care research, with over 50 scientific publications and patents. His deep clinical understanding of skin health, combined with the expertise of his research team, means Dermalogica can continue to advance skin care with innovative, evidence-based formulations.
our clinical results
visible differences, backed by science
We have an extensive collection of clinical results and white-papers that show the measurable impact of our professional products and protocols.
clinical summary
melanopro peel system
Melanopro Peel System is a clinical-strength peel programme that delivers visible results in less than 6 weeks. The transformative regimen works to visibly fade dark spots, reduce the appearance of hyperpigmentation, and smooth skin’s texture.
Using a combination of powerful, well-researched skin brightening actives, including Azelaic Acid, Tranexamic Acid, Retinol (Vitamin A), Niacinamide (Vitamin B3) and Acetyl Hexapeptide-1 (peptide), the system is an effective treatment for anyone who has hyperpigmentation concerns. The treatment has been shown to deliver results across a wide range of skin tones on the Fitzpatrick scale.
visible improvements in 6 weeks
Clinical experts assessed the impact of the melanopro peel system through a combination of in-vivo and in-vitro analysis. They were able to prove a significant reduction in the total number, overall area, and perimeter of dark spots, and a significant improvement in skin homogeneity at week 6.
clinical claims
After six weeks, the total number, area and perimeter of dark spots were significantly reduced.
After six weeks there was a significant improvement in skin homogeneity and a reduction in skin contrast.
After six weeks there was a significant increase in specular brightness.
clinical summary
pro restore recovery + firming concentrate
Pro Restore concentrate is designed to work with advanced skin services, preparing the skin’s barrier, restoring its condition and helping to improve the appearance of skin’s firmness and brightness. Suitable for use with microneedling, RF microneedling, Fibroblast Skin Tightening, lasers and chemical peels, Pro Restore reduces downtime, improves skin recovery, and amplifies results.
Panthenol (Pro-vitamin B5), mushroom extract and hyaluronic acid work to soothe, hydrate and strengthen the skin. Omega-3, Bacillus ferment and beta glucan help to restore the skin, helping to address post-procedure redness and irritation. Meanwhile, treatment results are amplified by the plant derived Oligopeptide-1 Epidermal growth factor, olive stem cell phospholipids and niacinamide.
These results were clinically validated by using a combination of in vitro testing, in vivo instrumental analysis, expert grading, and consumer perception, with visible benefits from first use.
how pro restore revolutionises skin healing
Clinical experts assessed visible skin rejuvenation using a validated dermatological scale system that measures erythema post treatment, skin luminosity and skin texture. This was a randomised, controlled, split-face study of 32 females aged 30-70 years for 4 weeks following microneedling treatment. Changes in skin condition were assessed by blinded clinical photography and expert evaluation. Measurements were collected at baseline, 1 hour, 1 day, 7 days and 28 days post treatment.
clinical claims
Erythema was significantly lower immediately after treatment, and was significantly reduced 7-days post treatment.
Luminosity was significantly increased immediately after treatment, 1 day after treatment and 7 days after treatment.
Tactile skin texture was significantly improved immediately, 1 day after treatment, 7 days after treatment, and 28 days after treatment.
clinical summary
Exo Booster
This bi-phase professional treatment takes advanced
services to the next level. Lactobacillus Exosomes deliver
encapsulated bioactives secreted by living cells to
combine with restorative Pro Resolution Technology, helping
to support natural cell renewal and boost skin’s vitality. Exo Booster provides a comprehensive approach to post-treatment skincare by boosting hydration, strengthening the skin barrier, and improving resilience.
These results were clinically validated by using a combination of in vitro testing, in vivo instrumental analysis, expert grading, and consumer perception, with visible benefits from first use.
what makes Exo Booster the perfect post-treatment enhancer?
The clinical data from microneedling-specific studies shows an 86% greater reduction in wrinkle appearance and 46% greater skin resilience compared to microneedling alone
clinical claims
Exo Booster is superior to human exosomes for aesthetic procedures
86% greater reduction in wrinkle appearance compared to treatment alone (21 days post procedure)
46% increase in skin resilience compared to treatment alone (21 days post procedure)
clinical summary
phyto nature e2
Over an 8-week period, 32 volunteers were involved in the clinical studies on Phyto Nature e2, delivering robust and statistically significant results. These results showed significant improvements in firmness, plumpness, radiance, roughness, lifting, fine lines and wrinkles, hydration, elasticity and overall skin appearance.
These results were clinically validated by using a combination of in vitro testing, in vivo instrumental analysis, expert grading, and consumer perception, with visible benefits from first use.
phyto nature e2 gives 6 years back
Formulated with next-generation exosomes and enzymes, this leave-on treatment reawakens the skin’s natural surface renewal process, improving natural regeneration by 86%. Exfoliating enzymes help clear away dull surface cells, revealing smoother, brighter skin. A regenerative exosome blend acts in multiple layers of skin’s surface, visibly diminishing fine lines and wrinkles.
clinical claims
Visibly reduced signs of skin ageing in 2 weeks
Fine lines + wrinkles were visibly reduced in 2 weeks
After 8 weeks skin’s natural regeneration improved by 86% and giving 6 years back
clinically backed skin health
the white paper library
White papers are research-based reports that summarise our clinically proven results and clearly explain the impact.
In our commitment to being transparent, authoritative and credible, we are sharing all existing white papers for your reading.
Melanopro White Paper: In Vitro and In Vivo Assessment of an Innovative Peeling System with Azelaic and Tranexamic Acids for Targeted Hyperpigmentation Reduction
Authors: Russell Wong, Mariangela G. de O. Sichmann, James Sun, Alexis R. Kim, Robert J. Bianchini, Kevin D. Hermanson, Louis Chabert
Published online: 20th April 2025